^ Jump up to: a b c d Boggs, Douglas L; Nguyen, Jacques D; Morgenson, Daralyn; Taffe, Michael A; Ranganathan, Mohini (6 September 2017). "Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol". Neuropsychopharmacology. 43 (1): 142–154. doi:10.1038/npp.2017.209. ISSN 0893-133X. PMC 5719112. PMID 28875990.
Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
There is also considerable potential for other industries using hemp in the manner that the automobile industry has demonstrated is feasible. Of course, all other types of transportation vehicles from bicycles to airplanes might make use of such technology. Natural fibers have considerable advantages for use in conveyance (Karus et al. 2000): low density and weight reduction, favorable mechanical, acoustical, and processing properties (including low wear on tools), no splintering in accidents, occupational health benefits (compared to glass fibers), no off-gassing of toxic compounds, and price advantages. Additional types of composite using hemp in combination with other natural fibers, post-industrial plastics or other types of resins, are being used to produce non-woven matting for padding, sound insulation, and other applications.

Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[142] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[143] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[144] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[145]


The CBD is often also the "city centre" or "downtown", but this is also often not the case. Midtown Manhattan is the largest central business district in New York City and in the world; yet Lower Manhattan, commonly called Downtown Manhattan, represents the second largest distinct CBD in New York City and is geographically situated south of Midtown. For example, London's "city centre" is usually regarded as encompassing the historic City of London and the mediaeval City of Westminster, whereas the City of London and the transformed Docklands area are regarded as its two CBDs. Mexico City also has a historic city centre, the colonial-era Centro Histórico, along with two CBDs: the mid-late 20th century Paseo de la Reforma - Polanco, and the new Santa Fe.

I've been waiting for weeks to receive this topical to see if I finally found a product that works and I'm so happy to say that I did! I've been dealing with knee pain that my doctor has not been able to officially diagnose and treat and it's extremely painful. This is the first product that I've tried that actually relieves most of the pain and pressure so I can continue to workout and stand without being in so much pain. Thank you for creating such an amazing product!

I was thinking about writing a separate article about CBD for cats since I’m a cat person myself, but until then here is some information for you… I haven’t seen much research regarding cats, and since they are much smaller animals than dogs, I presume THC is even more toxic to them. So, keep your stash away from your cat, and don’t smoke it near your pet.
This is a huge, HUGE step for N.C. First of all farmers can FINALLY make money off land that has grown tobacco for generations. FINALLY doubter I finding out there are many uses for the plant. Perhaps one of the biggest things is the impact on the environment. Most products, if not all, are biodegradable. Also, a huge factor is that in the field of medicine. Will this lead to medical and/or recreational marijuana? Time will tell. As for me, I quit smoking it 20 years ago. I do, however, believe any and all forms of cannabis should and will be made legal. Legal, if for no other reason, so we can stop making people who smoke it into criminals, filling up our jails and prisons. This will free up police, etc.. to finding real criminals. Last, but defiantly not least, IMHO, there is the N.C. aspect. That being I thought we would never, EVER see this time in N.C. Even if it is just industrial hemp for now, it’s a start. Who knows, in the not too distant future, legislatures and law enforcement will become open minded enough to legalize all forms of cannabis, HOPEFULLY. With the youth of these times moving into the right fields, and of course us boomers weighing in, it won’t be too long. AMEN
This cream is nothing short of amazing. I bought it for my mother who suffers from fibromyalgia. She was skeptical about CBD. Always worrying what Aunt Pat or so and so would think. I also gave her a Chong's choice strawberry vape pen. She was toking on her new vape while I applied the cream to her legs. About 5 minutes later, mom was like ...valerie...I don't feel the pins and needles in my legs... I don't feel the creepy crawling feeling. I...I...I don't have any pain in my legs. How is that possible?! And I say to her...and do you feel high?... Nope she says. Only pain free. I then say to her... screw what Aunt Pat thinks. Mom agrees...screw aunt pat and all the others like her. Ignorance is a major burden on the CBD as well as the cannabis industry. If people would just take the time to understand and learn about the whole plant, the world would be a much better place. Anyway... yeah this stuff is pretty freaking awesome. Mom is already asking how she gets a refill.
Henry Ford recognized the utility of hemp in early times. In advance of today’s automobile manufacturers, he constructed a car with certain components made of resin stiffened with hemp fiber (Fig. 19). Rather ironically in view of today’s parallel situation, Henry Ford’s hemp innovations in the 1920s occurred at a time of crisis for American farms, later to intensify with the depression. The need to produce new industrial markets for farm products led to a broad movement for scientific research in agriculture that came to be labeled “Farm Chemurgy,” that today is embodied in chemical applications of crop constituents.
Because the laws are regularly changing, always do your own due diligence. The best way to determine whether CBD is legal where you live is to look up CBD laws for your state. Some states have laws specific to CBD use and others do not. It is also prudent to have an understanding of the DEA’s stand on CBD for dogs or yourself, since this is often at odds with other state and federal regulations.

Industrial hemp comes from a variety of the Cannabis Sativa L plant. Our plants have concentration levels of 0.3% or less of delta 9 Tetrahydrocannabinol (THC), as defined by the 2014 Federal Farm Bill.Within the Cannabis Sativa L plant are molecules known as phytocannabinoids. All mammals have an endocannabinoid system that is nourished by phytocannabinoids.Non-cannabis plants that contain phytocannabinoids include chocolate (Theobroma cacao), black pepper (Piper nigrum), coneflower (Echinacea), among others.Humans naturally produce the cannabinoids Anandamide and 2-Arachidonoylglycerol (2-AG). Delta 9 Tetrahydrocannabinol (THC) is the only phytocannabinoid that is proven to create a psychoactive effect.In the raw plant state, the THC molecule is confined within a different non-psychoactive phytocannabinoid known as THCA. Our PurCBD oil is non-psychoactive and contains other phytocannabinoids found in the industrial hemp plant including but not limited to phytocannabidiol, which have been reported to have anti-inflammatory, anti-anxiety, and anti-seizure properties. When phytocannabidiol is derived from the seeds and stalks of an industrial hemp plant it is legal in all 50 states,just like any other essential oil such as lavender or peppermint.


A chief argument that has been advanced in favor of developing hemp as a paper and pulp source has been that as a non-wood or tree-free fiber source, it can reduce harvesting of primary forests and the threat to associated biodiversity. It has been claimed that hemp produces three to four times as much useable fiber per hectare per annum as forests. However, Wong (1998) notes evidence that in the southern US hemp would produce only twice as much pulp as does a pine plantation (but see discussion below on suitability of hemp as a potential lumber substitute in areas lacking trees).
Fiberboard. In North America the use of nonwood fibers in sheet fiberboard (“pressboard” or “composite board”) products is relatively undeveloped. Flax, jute, kenaf, hemp, and wheat straw can be used to make composite board. Wheat straw is the dominant nonwood fiber in such applications. Although it might seem that hemp bast fibers are desirable in composite wood products because of their length and strength, in fact the short fibers of the hurds have been found to produce a superior product (K. Domier, pers. commun.). Experimental production of hemp fiberboard has produced extremely strong material (Fig. 22). The economic viability of such remains to be tested. Molded fiberboard products are commercially viable in Europe (Fig. 23), but their potential in North America remains to be determined.
In Europe and Asia, hemp farming has been conducted for millennia. Although most countries ceased growing hemp after the second word war, some didn’t, including France, China, Russia, and Hungary, so that essential knowledge of how to grow and process hemp was maintained. When commercial hemp cultivation resumed in Canada in 1997, many farmers undertook to grow the crop without appreciating its suitability for their situation, or for the hazards of an undeveloped market. Hemp was often grown on farms with marginal incomes in the hopes that it was a savior from a downward financial spiral. The myth that hemp is a wonder crop that can be grown on any soil led some to cultivate on soils with a history of producing poor crops; of course, a poor crop was the result.
×